The majority of children with autism, which is caused due to genetic factors are depressed, can get care anti-depressant drugs such as Prozac (fluoxetine), a statement from Dr. Robert DeLong, a specialist neurologist at Duke University, England.
At a journal Neurology, March 23 edition, DeLong presents a new hypothesis about two-thirds of children suffering from infantile autism. The reality of these children can be cured. Unconformity genetics, is a form of the initial attack of severe depression. DeLong argument based on the current genetic analysis, research on behavior, brain chemistry, and analysis of concepts in children with autism, through research at Duke University and other institutes.
The results:
"Research on the genetics and brain concepts, as well as a re-examination of the classic symptoms of autism, suggesting that many autistic children suffer from autism not because of heredity, and we know how to handle it," said DeLong.
Children with autism appear as if they were shackled by their own minds, because they can not learn the language, or social skills needed in the environment.
In fact autism is a spectrum of disorders with symptoms that are similar, DeLong said. Autistic children, in the second year of life they usually lose the ability to interact with the people in his neighborhood and did not speak, or using language, although many of them have normal intelligence.
Some people with autism is caused by diseases or injuries in certain areas of the brain, but most cases are not known, referred to as idiopathic cases. DeLong said that 70 percent of people with an unpleasant disharmony, such as mental retardation or disorders that suppress thoughts, not because of heredity.
"Several years ago I noticed, when we look carefully the symptoms of autism, the symptoms are more noticeable as depression and mental disharmony," said DeLong.
"These kids do not show excitement or spontaneity that usually seen in normal children. And they often show extreme beat of desire, anger and fear is excessive."
De Long has found a variety of directions, from the research group of children with autism, who suffer from autism as a genetic disease. Seen the same thing happen to these children, ie they can be treated with antidepressant medication.
When the researchers studied the brains of children with idiopathic autism, they found the neurotransmitter serotonin is very low on the left brain in the area of language use. Serotonin is also important to influence mood. In people who suffer from clinical depression, serotonin is very low.
"The brain development of children, serotonin not only acts as a transmitter of information, but also as an agent (a substance, power) that affect the growth of brain development," said DeLong. "If the rank of serotonin in the left hemisphere did not reach critical ratings in early childhood, people will be able to see the symptoms as suffered autism: impaired cognitive development, social and emotional."
Research on people with brains who underwent surgery to separate the relationship between left hemisphere and right hemisphere, in order to relieve the symptoms of epilepsy, usually called the experiment "split-brain", the left side of the brain showed a driver of language skills and cause and effect, while the brain the right of the driver visual skills, body movement, music and memorization skills. Serotonin levels in the brain to the right of the majority of children with idiopathic autism and normal visual skills as well as their body movements are also normal. In fact, many autistic savants show a type of excess in the right brain, which gives them extraordinary abilities in the skills of counting, mathematical, musical or artistic.
When the researchers studied children who were older and adolescents who were diagnosed as mental disharmony, they found that these children have visual capabilities and a larger body movements, but the low language skills, although not for autistic children.
These discoveries led DeLong to try treating autistic children with Prozac (fluo-xetine) and some special drug prevention was hambatnya serotonin (SSRls). These drugs are drugs for treating depression, work more serotonin in the brain.
Reports a study in October 1998, published by the Journal of Developmental Medicine and Child Neurology, DeLong and his colleagues reported that when the 37 autistic children ages 3 to 7 years were treated with Prozac (fluoxetine) for three years, 22 responded well to the medication, regain language skills, the ability to increase social skills and obsessive compulsions such as fixating on a single object for hours and hours will be lost. Of the children who responded to the medication, all had a history of major depressive illness of his family.
"It was interesting to say that autism and mental disharmony caused by the same cause, namely the defective gene," DeLong said, "And the fact of the gene from that direction."
The study by DeLong and his colleagues at Duke University points to a gene somewhere on chromosome 15, as a potential autism gene. And now many studies on depression in various educational institutions show similar results, namely chromosome 15, as the genes of potential mental disharmony.
"Although we have not been able to ensure that the gene is only one and the same, but the fact is encouraging, and hopefully soon we can get the answer," said DeLong.
"Research on the genetics, giving hope to the initial diagnosis," said DeLong, and the development of more specific treatments to improve the procurement of serotonin in the brain development of children with autism will add even hope for an effective treatment for this disease.
"Rather than think of autism as a disease that can not be cured, we should see it as a treatable disease, it's better than having no hope," said DeLong. "My hope is that subsequent studies can identify and intervene early with autism, that autism is a disease that can be addressed through treatment."
At a journal Neurology, March 23 edition, DeLong presents a new hypothesis about two-thirds of children suffering from infantile autism. The reality of these children can be cured. Unconformity genetics, is a form of the initial attack of severe depression. DeLong argument based on the current genetic analysis, research on behavior, brain chemistry, and analysis of concepts in children with autism, through research at Duke University and other institutes.
The results:
"Research on the genetics and brain concepts, as well as a re-examination of the classic symptoms of autism, suggesting that many autistic children suffer from autism not because of heredity, and we know how to handle it," said DeLong.
Children with autism appear as if they were shackled by their own minds, because they can not learn the language, or social skills needed in the environment.
In fact autism is a spectrum of disorders with symptoms that are similar, DeLong said. Autistic children, in the second year of life they usually lose the ability to interact with the people in his neighborhood and did not speak, or using language, although many of them have normal intelligence.
Some people with autism is caused by diseases or injuries in certain areas of the brain, but most cases are not known, referred to as idiopathic cases. DeLong said that 70 percent of people with an unpleasant disharmony, such as mental retardation or disorders that suppress thoughts, not because of heredity.
"Several years ago I noticed, when we look carefully the symptoms of autism, the symptoms are more noticeable as depression and mental disharmony," said DeLong.
"These kids do not show excitement or spontaneity that usually seen in normal children. And they often show extreme beat of desire, anger and fear is excessive."
De Long has found a variety of directions, from the research group of children with autism, who suffer from autism as a genetic disease. Seen the same thing happen to these children, ie they can be treated with antidepressant medication.
When the researchers studied the brains of children with idiopathic autism, they found the neurotransmitter serotonin is very low on the left brain in the area of language use. Serotonin is also important to influence mood. In people who suffer from clinical depression, serotonin is very low.
"The brain development of children, serotonin not only acts as a transmitter of information, but also as an agent (a substance, power) that affect the growth of brain development," said DeLong. "If the rank of serotonin in the left hemisphere did not reach critical ratings in early childhood, people will be able to see the symptoms as suffered autism: impaired cognitive development, social and emotional."
Research on people with brains who underwent surgery to separate the relationship between left hemisphere and right hemisphere, in order to relieve the symptoms of epilepsy, usually called the experiment "split-brain", the left side of the brain showed a driver of language skills and cause and effect, while the brain the right of the driver visual skills, body movement, music and memorization skills. Serotonin levels in the brain to the right of the majority of children with idiopathic autism and normal visual skills as well as their body movements are also normal. In fact, many autistic savants show a type of excess in the right brain, which gives them extraordinary abilities in the skills of counting, mathematical, musical or artistic.
When the researchers studied children who were older and adolescents who were diagnosed as mental disharmony, they found that these children have visual capabilities and a larger body movements, but the low language skills, although not for autistic children.
These discoveries led DeLong to try treating autistic children with Prozac (fluo-xetine) and some special drug prevention was hambatnya serotonin (SSRls). These drugs are drugs for treating depression, work more serotonin in the brain.
Reports a study in October 1998, published by the Journal of Developmental Medicine and Child Neurology, DeLong and his colleagues reported that when the 37 autistic children ages 3 to 7 years were treated with Prozac (fluoxetine) for three years, 22 responded well to the medication, regain language skills, the ability to increase social skills and obsessive compulsions such as fixating on a single object for hours and hours will be lost. Of the children who responded to the medication, all had a history of major depressive illness of his family.
"It was interesting to say that autism and mental disharmony caused by the same cause, namely the defective gene," DeLong said, "And the fact of the gene from that direction."
The study by DeLong and his colleagues at Duke University points to a gene somewhere on chromosome 15, as a potential autism gene. And now many studies on depression in various educational institutions show similar results, namely chromosome 15, as the genes of potential mental disharmony.
"Although we have not been able to ensure that the gene is only one and the same, but the fact is encouraging, and hopefully soon we can get the answer," said DeLong.
"Research on the genetics, giving hope to the initial diagnosis," said DeLong, and the development of more specific treatments to improve the procurement of serotonin in the brain development of children with autism will add even hope for an effective treatment for this disease.
"Rather than think of autism as a disease that can not be cured, we should see it as a treatable disease, it's better than having no hope," said DeLong. "My hope is that subsequent studies can identify and intervene early with autism, that autism is a disease that can be addressed through treatment."
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